Development and Pharmaceutical Applications of Functional Stationary Phases for Capillary Electrochromatography and Chiral Separation
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چکیده
منابع مشابه
Focusing Review Development and Pharmaceutical Applications of Functional Stationary Phases for Capillary Electrochromatography and Chiral Separation
We synthesized 3-(4-sulfo-1,8-naphthalimido)propyl-modified silica (SNAIP) for capillary electrochromatography (CEC). The unique structure of SNAIP contributed to the retention by three interactions including hydrophobic, electrostatic and interactions and the acceleration of electroosmotic flow at an acidic condition. The CEC employing SNAIP was successively applied to the rapid separations of...
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Since the turn of the twentieth century, it has been recognized that many drugs, agrochemicals, food additives and fragrances are chiral compounds and their chirality may considerably affect their bioactive behavior [1, 2]. The demand has been increasing for new analytical methods with high selectivity and efficiency. Chiral separation has become an attractive and important field in the separat...
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Enantiomer separation of mandelates and their analogs, which are important intermediates in asymmetric synthetic and pharmaceutical chemistry, was investigated by capillary gas chromatography using different cyclodextrin derivative chiral stationary phases (CD CSPs). The used cyclodextrin derivatives included permethylated beta-CD (PMBCD), permethylated gamma-CD, heptakis(2,6-di-O-butyl-3-O-but...
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This review summarizes recent developments in chiral separation in capillary zone electrophoresis (CZE), electrokinetic chromatography (EKC), and capillary electrochromatography (CEC) covering literature published since the year 2000. New chiral selectors and innovative approaches for CE and CEC are introduced. Recent progress in column technology for CEC is highlighted and the development of n...
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ژورنال
عنوان ژورنال: CHROMATOGRAPHY
سال: 2014
ISSN: 1342-8284,1348-3315
DOI: 10.15583/jpchrom.2014.001